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VPHOP - The Osteoporotic Virtual Physiological Human

  • 17765
  • CORDIS - PROJECTS 08/05/2008

Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the skeletal determinants but also the neuromuscular condition.

The aim of VPHOP is to develop a multiscale modelling technology based on conventional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the absolute risk of bone fracture will be much more accurate than any prediction based on external and indirect determinants, as it is current clinical practice.

These predictions will be used to:

  • improve the diagnostic accuracy of the current clinical standards;
  • to provide the basis for an evidence-based prognosis with respect to the natural evolution of the disease, to pharmacological treatments, and/or to preventive interventional treatments aimed to selectively strengthen particularly weak regions of the skeleton.

For patients at high risk of fracture, and for which the pharmacological treatment appears insufficient, the VPHOP system will also assist the interventional radiologist in planning the augmentation procedure. The various modelling technologies developed during the project will be validated not only in vitro, on animal models, or against retrospective clinical outcomes, but will also be assessed in term of clinical impact and safety on small cohorts of patients enrolled at four different clinical institutions, providing the factual basis for effective clinical and industrial exploitations.


Start date: 2008-09-01
End date: 2012-08-31

Duration: 48 months

Project Reference: 223865

Project cost: 12073349 EURO
Project Funding: 8989363 EURO

Subprogramme Area: Virtual physiological human
Contract type: Virtual physiological human

Coordinatore: Istituto Ortopedico Rizzoli - Marco Viceconti

Altri Partecipanti

  • Technische Universiteit Eindhoven - NL
  • Empirica Gesellschaft für Kommunikations- und Technologieforschung mbH - DE
  • SCS srl - IT
  • Charité - Universitätsmedizin Berlin - DE
  • Eidgenössische Technische Hochschule Zuerich - CH
  • Universite de Geneve - CH
  • Universitaet Bern - CH
  • Sylvia Lawry Centre for Multiple Sclerosis Research e.V. - DE
  • ANSYS France SAS - FR
  • Katholieke Universiteit Leuven - BE
  • University of Bedfordshire - UK
  • Haskoli Islands - IS
  • Uppsala Universitet - SE
  • Institut National de la Santé et de la Recherche Médicale - FR
  • Biospace med SA - FR
  • Societe d'Etudes et de Recherches de l'Ecole Nationale Superieure d'Arts et Metiers - FR
  • BrainLAB AG - DE
  • Philips Medical Systems Nederland BV - NL
Quadro di finanziamento
  • 7FP-ICT : TECNOLOGIE DELL’INFORMAZIONE E DELLA COMUNICAZIONE: priorità tematica 3 nell'ambito del programma specifico “Cooperazione” recante attuazione del Settimo programma quadro (2007-2013) di attività comunitarie di ricerca, sviluppo tecnologico e dimostrazione
Area di interesse
  • Unione Europea