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MAGISTER - Magnetic scaffolds for in vivo tissue engineering

  • 19321
  • CORDIS - PROJECTS 20/02/2009
  • RISULTATO

The main driving idea of the project is the creation of conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and ostheocondral lesions in the articular surface of the skeletal system. The major limitations of the scaffolds for bone and cartilage regeneration nowadays available in the market are related to the difficulties in controlling cell differentiation and angiogenesis processes and to obtain stable scaffold implantation in the pathological site. . . Several attempts have been performed over the last years in order to provide scaffolds for tissue engineering, but nowadays there is no way to grant that tissue regeneration take place in the pathological site.
The provision in vivo of the scaffold with staminal cells or /and growth factors in order to drive the tissue differentiation process and parallel angiogenesis represents nowadays one of most challenging requests [Ref. Nanomedicine roadmap]. The Consortium aims to elaborate, investigate and fabricate new kind of scaffolds magnetic scaffolds (MagS) - characterized by strongly enhanced control and efficiency of the tissue regeneration and angiogenic processes. The magnetic moment of the scaffolds enables them with a fascinating possibility of being continuously controlled and reloaded from external supervising centre with all needed scaffold materials and various active factors (AF). Such a magnetic scaffold can be imagined as a fixed station that offers a long-living assistance to the tissue engineering, providing thus a unique possibility to adjust the scaffold activity to the personal needs of the patient.



Start date: 2008-12-01
End date: 2012-11-30

Duration: 48 months

Project Reference: 214685

Project cost: 11.09 million euro
Project Funding: 8.28 million euro

Subprogramme Area: NMP-2007-2.3-1 Highly porous bioactive scaffolds favouring angiogenesis for tissue engineering
Contract type: Large-scale integrating project



Coordinatore: CONSIGLIO NAZIONALE DELLE RICERCHE - ITALY - DEDIU, Valentin (Dr)

Altri Partecipanti

  • BIO-VAC ESPANA SA - SPAIN
  • FIN-CERAMICA FAENZA SPA - ITALY
  • CENTRAL INSTITUTE OF ORTHOPEDICS AND TRAUMATOLOGY OF RUSSIA - RUSSIAN FEDERATION
  • AVANTICELL SCIENCE LTD - UNITED KINGDOM
  • BELARUSSIAN STATE MEDICAL UNIVERSITY - BELARUS
  • BIODEVICE SYSTEMS SRO - CZECH REPUBLIC
  • I+ SRL - ITALY
  • INVENT SAS - FRANCE
  • SVEUCILISTE U ZAGREBU, MEDICINSKI FAKULTET - CROATIA
  • EXPLORA SRL - ITALY
  • FORSCHUNGSZENTRUM DRESDEN-ROSSENDORF EV - GERMANY
  • UNIVERSIDADE DE SANTIAGO DE COMPOSTELA - SPAIN
  • UNIVERSITAETSSPITAL BASEL - SWITZERLAND
  • EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT - SWITZERLAND
  • UNIVERSITY OF BRIGHTON
  • ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA ITALY
  • RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG.
  • GERMANY - THE UNIVERSITY OF EDINBURGH
  • UNITED KINGDOM - UNIVERSIDAD POLITECNICA DE VALENCIA
  • SPAIN - SPAIN
Link
Quadro di finanziamento
  • 7FP-NMP : NANOSCIENZE, NANOTECNOLOGIE, MATERIALI E NUOVE TECNOLOGIE DI PRODUZIONE: priorità tematica 4 nell'ambito del programma specifico “Cooperazione” recante attuazione del Settimo programma quadro (2007-2013) di attività comunitarie di ricerca, sviluppo tecnologico e dimostrazione
Area di interesse
  • Unione Europea