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BIOSCENT - Bioactive highly porous and injectable scaffolds controlling stem cell recruitment, proliferation and differentiation and enabling angiogenesis for cardiovascular engineered tissues

  • 19730
  • CORDIS - PROJECTS 27/04/2009
  • RISULTATO

Congenital and acquired diseases of the heart are the leading causes of morbidity and mortality in the world today; 7.2 million people die each year due to coronary heart disease, being the first cause of mortality in population above 60 years old, and the second cause after HIV in world wide young population. There is an urgent demand for new methods to repair and replace damaged cardiovascular tissues. One of the most promising ways to achieve this goal is the development of regenerative therapies aided with novel intelligent nanobiomaterials such as bioactive scaffolds.
The overall objective of this project is the development of innovative bioactive polymeric scaffolds able to guide tissue formation from dissociated stem cells, for engineering autologous cardiovascular replacements, namely vascular tissues, heart valves and cardiac muscle. Two different strategies will be followed to approach creating new engineered tissue:

  • In vitro tissue engineering: according to the most frequent tissue engineering paradigm, cells will be seeded on a scaffold composed of synthetic polymer or natural material and the tissue will be matured in vitro in a bioreactor, in order to obtain a construct that can be implanted in the appropriate anatomic location as a prosthesis;
  • In vivo tissue engineering: unseeded scaffolds that attract endogenous cells and control cell proliferation and differentiation will be implanted to repopulate and remodel an altered cardiovascular tissue.

The strong innovative content of the project is in the realisation of multifunctional scaffolds which can guide complex cellular processes such as adhesion, proliferation and differentiation, processes fundamental for tissue regeneration. It is therefore necessary to design integrated material scaffolds and culture environments, which can appropriately confer biochemical, morphological, electrical and mechanical stimuli to a developing tissue.



Start date: 2009-01-01
End date: 2013-12-31

Duration: 60 months

Project Reference: 214539

Project cost: 8.34 million euro
Project Funding: 6.31 million euro

Subprogramme Area: NMP-2007-2.3-1 Highly porous bioactive scaffolds favouring angiogenesis for tissue engineering
Contract type: Large-scale integrating project



Coordinatore: UNIVERSITA DI PISA - ITALY - GIUSTI, Paolo (Professor)

Altri Partecipanti

  • KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW - NETHERLANDS
  • INSTITUTUL DE CHIMIE MACROMOLECULARA PETRU PONI - ROMANIA
  • IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE - UNITED KINGDOM
  • USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE - CZECH REPUBLIC
  • GMBH IBT - IMMUNOLOGICAL AND BIOCHEMICALTESTSYSTEMS GMBH* - GERMANY
  • CAMBRIDGE RESEARCH BIOCHEMICALS - UNITED KINGDOM
  • CHEMPILOTS A/S - DENMARK
  • SORIN BIOMEDICA CARDIO S.R.L. - ITALY
  • UNIVERSITA DEGLI STUDI DI PARMA - ITALY
  • IMM RECHERCHE SAS - FRANCE
  • POLITECNICO DI TORINO - ITALY
  • PERA INNOVATION LIMITED - UNITED KINGDOM
  • MEDIZINISCHE HOCHSCHULE HANNOVER - GERMANY
  • THE UNIVERSITY OF MANCHESTER - UNITED KINGDOM
Link
Quadro di finanziamento
  • 7FP-NMP : NANOSCIENZE, NANOTECNOLOGIE, MATERIALI E NUOVE TECNOLOGIE DI PRODUZIONE: priorità tematica 4 nell'ambito del programma specifico “Cooperazione” recante attuazione del Settimo programma quadro (2007-2013) di attività comunitarie di ricerca, sviluppo tecnologico e dimostrazione
Area di interesse
  • Unione Europea