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BIOCHEMLIG - Bio-orthogonal chemo-specific ligation

  • 20850
  • CORDIS - PROJECTS 02/10/2009
  • RISULTATO

The Post-genomic era calls for a deep understanding of protein structure and function. The elucidation of protein structures, localization, post-translation modifications, and protein-macromolecule interactions are important to establish their role in the biology of the cell. To establish their role and investigate the protein functions requires the integration of various complementary disciplines.
Among all disciplines, chemistry is central in establishing new effective ways to manipulate a biological entity to understand cellular processes with molecular precision. For studying, analyzing and manipulating a macromolecule, the site-specific incorporation of reporter molecules, by virtue of ligation reactions, is a key factor.
The BioChemLig research project presented herein describes novel approaches for the discovery of new bio-compatible and chemo-specific ligation reactions. The aim of this project is to develop new ligation processes with high efficiency, large scope of application, high chemoselectivity and high rates.
Through a well established network, with demonstrated success (IBAAC Project: FP6-505020), we propose to focus our efforts in a highly combined and integrated training research action conducting research and using: unusual organic chemical functionalities for ligation, environmentally benign on water ligation reactions, specific 18F radiolabelled reagents, dendrimers conjugation methodologies, high-throughput screening for bond forming reactions, bio-chemo informatics platform for theoretical investigations, artificial metalo-enzymes for template-directed ligation, templated ligation reactions and HTS.
This high quality integrated research should ultimately allow scientists to dissect cellular processes with molecular precision, speed up preparation of library of bioconjugates and deliver innovative approaches to chemical biology.



Start date: 2009-10-01
End date: 2013-09-30

Duration: 48 months

Project Reference: 238434

Project cost: 3.32 million euro
Project Funding: 3.32 million euro

Subprogramme Area: FP7-PEOPLE-ITN-2008 Marie Curie Action: 'Networks for Initial Training'
Contract type: Networks for Initial Training (ITN)



Coordinatore: UNIVERSITE DE STRASBOURG - FRANCE - PETIN-MONTEIL, Laurence (Ms.)

Altri Partecipanti

  • NUEVOLUTION A/S - DENMARK
  • COMMISSARIAT A L' ENERGIE ATOMIQUE - FRANCE
  • UNIVERSITAET BASEL - SWITZERLAND
  • KEMIJSKI INSTITUT - SLOVENIA
  • UNIVERSITAET BERN - SWITZERLAND
  • ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA - ITALY
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - UNITED KINGDOM
Link
Quadro di finanziamento
  • 7FP-PEOPLE : PERSONE: programma specifico del Settimo programma quadro (2007-2013) di attività comunitarie di ricerca, sviluppo tecnologico e dimostrazione
Area di interesse
  • Unione Europea