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DISCHROM - Chromatin diseases: from basic mechanisms to therapy

  • 20913
  • CORDIS - PROJECTS 03/11/2009
  • RISULTATO

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies; so far for the vast majority of them no treatment is as yet available. Molecular studies on these pathologies thus have a twofold value: to shed light on the intricate interplays between different levels of control of gene expression acting in the mammalian nucleus and to pave the way toward new and more effective strategies to approach the treatment of this increasing class of diseases.
Our students will take advantage of the integrated approach on multilayered gene regulation, the multidisciplinary nature and the cutting-edge methodologies, which are an integral part of this proposal. We thus expect to provide a framework for the very high-level training of young researchers, receiving a strong background in molecular, cellular and developmental biology, genomics, bioinformatics, chromatin biology and epigenetics. Furthermore, they will develop expertise in many cutting edge methodologies and tools, such as imaging, high throughput gene technologies, ChIP.
As a result, the ESRs will be highly competitive in performing independent research in various areas of biology and will represent a new breed of scientists trained in contemporary post-genomic biology using advanced technological tools to tackle human disease.



Start date: 2009-11-01
End date: 2013-10-31

Duration: 48 months

Project Reference: 238242

Project cost: 2.57 million euro
Project Funding: 2.57 million euro

Subprogramme Area: FP7-PEOPLE-ITN-2008 Marie Curie Action: 'Networks for Initial Training'
Contract type: Networks for Initial Training (ITN)



Coordinatore: CONSIGLIO NAZIONALE DELLE RICERCHE - ITALY - BALDINI, Antonio (Professor)

Altri Partecipanti

  • UNIVERSITA DEGLI STUDI DELL'INSUBRIA - ITALY
  • DIAGENODE SA - BELGIUM
  • FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE - SPAIN
  • UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II - FRANCE
  • BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING - GREECE
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - UNITED KINGDOM
  • UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA - ITALY
  • UNIVERSITY COLLEGE LONDON - UNITED KINGDOM
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE - UNITED KINGDOM
Link
Quadro di finanziamento
  • 7FP-PEOPLE : PERSONE: programma specifico del Settimo programma quadro (2007-2013) di attività comunitarie di ricerca, sviluppo tecnologico e dimostrazione
Area di interesse
  • Unione Europea