- CORDIS - PROJECTS 19/05/2008
NeoMark will perform research in the integration of heterogeneous clinical, laboratory, molecular and imaging data to develop a data integration environment facilitating multiscale and multilevel modeling, aimed at advancing models and methods currently in use to predict neoplastic reoccurrences, and to apply it to the study of oral cancer. Specifically the scientific target will be to apply this multi-level data integration environment to the monitoring of the disease after remission, in order to early identify local or metastatic reoccurrence of the disease.
The technical target will be the development of two functional environments: one for the definition of biomarker profiles and one for the follow-up of the evolution of the disease. They will be based on the 'fusion' of information from clinical data from health records and standard laboratory markers; from histological data from tumor mass specimens; from high-throughput genomic data from tumor tissue specimens, profiling gene expression at whole-genome level by oligo-RNA microarrays; from high-throughput genomic data from circulating cells specimens (whole blood sample), profiling gene expression at whole-genome level by oligo-RNA microarrays; from imaging data of the prime tumor mass (and secondary localizations if present) through imaging techniques, including image fusion, where relevant.
The outcomes of the project will be validated in two primary Clinical Centers in Spain and in Italy. In this phase the early exploitation of NeoMark will also be assessed through the use of a RT-PCR platform to develop highly individual diagnostic tests to be used both at the time of first diagnosis, as well as for reoccurrence identification.
Start date: 2008-06-01
End date: 2010-08-31
Duration: 27 months
Project Reference: 224483
Project cost: 4205555 EURO
Project Funding: 2896600 EURO
Subprogramme Area: Virtual physiological human
Contract type: Collaborative project (generic)
Coordinatore: AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA - PARMA ITALIA - Pioppi, Franco
- FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. - MUENCHEN DEUTSCHLAND
- PANEPISTIMIO IOANNINON - IOANNINA HELLAS
- STMICROELECTRONICS S.R.L. - AGRATE BRIANZA ITALIA
- FUNDACION MD ANDERSON INTERNATIONAL ESPANA - MADRID ESPAÑA
- PLANET AE - ATHINA HELLAS
- UNIVERSIDAD POLITECNICA DE MADRID - MADRID ESPAÑA
- LINK CONSULTING - TECNOLOGIAS DE INFORMACAO S.A. - LISBOA PORTUGAL
- MULTIMED S.R.L. - CREMONA ITALIA
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