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AIRPROM - Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling

  • 23573
  • CORDIS - PROJECTS 14/02/2011
  • RISULTATO

The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of 56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM), brings together the existing clinical consortia (EvA FP7, U-BIOPRED IMI and BTS Severe Asthma), and expertise in physiology, radiology, image analysis, bioengineering, data harmonization, data security and ethics, computational modelling and systems biology. We shall develop an integrated multi-scale model building upon existing models.

This airway model will be comprised of an integrated micro-scale and macro-scale airway model informed and validated by omic data and ex vivo models at the genome-transcriptome-cell-tissue scale and by CT and functional MRI imaging coupled to detailed physiology at the tissue-organ scale utilising Europe's largest airway disease cohort. Validation will be undertaken cross-sectionally, following interventions and after longitudinal follow-up to incorporate both spatial and temporal dimensions.

AirPROM has a comprehensive data management platform and a well-developed ethico-legal framework. Critically, AirPROM has an extensive exploitation plan, involving at its inception and throughout its evolution those that will develop and use the technologies emerging from this project. AirPROM therefore will bridge the critical gaps in our clinical management of airways disease, by providing validated models to predict disease progression and response to treatment and the platform to translate these patient-specific tools, so as to pave the way to improved, personalised management of airways disease.


Start date: 2011-03-01
End date: 2016-02-29

Duration: 60 months

Project Reference: 270194

Project cost: 15.53 million euro
Project Funding: 11.71 million euro

Subprogramme Area: ICT-2009.5.3 Virtual Physiological Human
Contract type: Collaborative project (generic)


Coordinatore: UNIVERSITY OF LEICESTER - Marie ADAMS

Altri Partecipanti

  • UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II - FRANCE
  • COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES - FRANCE
  • THE UNIVERSITY OF MANCHESTER - UNITED KINGDOM
  • QUEEN'S UNIVERSITY BELFAST - UNITED KINGDOM
  • EUROPEAN LUNG FOUNDATION - UNITED KINGDOM
  • THE UNIVERSITY OF WARWICK - UNITED KINGDOM
  • IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE - UNITED KINGDOM
  • UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NATIONAL HEALTH SERVICE TRUST - UNITED KINGDOM
  • UNIVERSITY OF SOUTHAMPTON - UNITED KINGDOM
  • EUROPEAN RESPIRATORY SOCIETY - SWITZERLAND
  • VASTRA GOTALANDS LANS LANDSTING - SWEDEN
  • UMEA UNIVERSITET - SWEDEN
  • KAROLINSKA INSTITUTET - SWEDEN
  • FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA - SPAIN
  • INSTYTUT GRUZLICY I CHOROB PLUC - POLAND
  • UNIVERSITA DEGLI STUDI DI FERRARA - ITALY
  • UNIVERSITA DEGLI STUDI DI CATANIA - ITALY
  • ORSZAGOS KORANYI TBE ES PULMONOLOGIAI INTEZET - HUNGARY
  • INSTITUT TELECOM - FRANCE
  • BIOSCI CONSULTING - BELGIUM
  • FLUIDDA NV - BELGIUM
  • MATERIALISE NV - BELGIUM
  • EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING - BELGIUM
  • SEMMELWEIS EGYETEM - HUNGARY
  • BIOMAX INFORMATICS AG - GERMANY
  • OBJET GEOMETRIES GMBH - GERMANY
  • ANSYS UK LIMITED - UNITED KINGDOM
  • THE UNIVERSITY OF SHEFFIELD - UNITED KINGDOM
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - UNITED KINGDOM
  • ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM - NETHERLANDS
  • HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH - GERMANY
  • INSTYTUT CHEMII BIOORGANICZNEJ PAN - POLAND
  • THE UNIVERSITY OF NOTTINGHAM - UNITED KINGDOM
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Quadro di finanziamento
  • 7FP-ICT : TECNOLOGIE DELL’INFORMAZIONE E DELLA COMUNICAZIONE: priorità tematica 3 nell'ambito del programma specifico “Cooperazione” recante attuazione del Settimo programma quadro (2007-2013) di attività comunitarie di ricerca, sviluppo tecnologico e dimostrazione
Area di interesse
  • Unione Europea