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CHIC - Computational Horizons In Cancer (CHIC): Developing Meta- and Hyper-Multiscale Models and Repositories for In Silico Oncology

  • 29463
  • CORDIS - PROJECTS 01/04/2013
  • RISULTATO

Developing robust, reproducible, interoperable and collaborative hyper-models of diseases and normal physiology is a sine qua non necessity if rational, coherent and comprehensive exploitation of the invaluable information hidden within human multiscale biological data is envisaged. Responding to this imperative in the context of both the broad Virtual Physiological Human (VPH) initiative and the paradigmatic cancer domain, CHIC proposes the development of a suite of tools, services and secure infrastructure that will support accessibility and reusability of VPH mathematical and computational hypermodels. These will include a hypermodelling infrastructure consisting primarily of a hypermodelling editor and a hypermodelling execution environment, an infrastructure for semantic metadata management, a hypermodel repository, a hypermodel-driven clinical data repository, a distributed metadata repository and an in silico trial repository for the storage of executed simulation scenarios. Multiscale models and data will be semantically annotated using the ontological and annotating tools to be developed. An image processing and visualization toolkit, and cloud and virtualization services will also be developed. The CHIC tools, services, infrastructure and repositories will provide the community with a collaborative interface for exchanging knowledge and sharing work in an effective and standardized way. A number of open source features and tools will enhance usability and accessibility. In order to ensure clinical relevance and foster clinical acceptance of hypermodelling in the future, the whole endeavour will be driven by the clinical partners of the consortium. Cancer hypermodels to be collaboratively developed by the consortium cancer modellers will provide the framework and the testbed for the development of the CHIC technologies. Clinical adaptation and partial clinical validation of hypermodels and hypermodel oncosimulators will be undertaken.


Start date: 01-04-2013
End date: 31-03-2017
Duration: 48 months
Project Reference: 600841
Project cost: 13907967 EURO
Project Funding: 10582000 EURO
Subprogramme Area: Virtual Physiological Human (c)
Contract type: Collaborative project (generic)


Coordinatore: INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS - Georgios STAMATAKOS (Dr) MICROWAVE AND FIBER OPTICS LABORATORY (HELLAS) 

Altri Partecipanti

  • FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (HELLAS)
  • PHILIPS ELECTRONICS NEDERLAND B.V. (NEDERLAND)
  • UNIVERSITAET DES SAARLANDES - EUSERVICE (DEUTSCHLAND)
  • EUROPEAN RESEARCH AND PROJECT OFFICE GMBH (DEUTSCHLAND)
  • CUSTODIX NV - CUSTODIX (BELGIQUE)
  • UNIVERSITY COLLEGE LONDON - EUROPEAN RESEARCH AND DEVELOPMENT OFFICE (UNITED KINGDOM)
  • KATHOLIEKE UNIVERSITEIT LEUVEN - KU LEUVEN RESEARCH & DEVELOPMENT (BELGIQUE)
  • THE UNIVERSITY OF SHEFFIELD - RESEARCH FINANCE (UNITED KINGDOM)
  • GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER - INSTITUT FR RECHTSINFORMATIK (DEUTSCHLAND)
  • TECHNOLOGICAL EDUCATIONAL INSTITUTE OF CRETE - SCHOOL OF MANAGEMENT AND FINANCE (HELLAS)
  • CONSORZIO INTERUNIVERSITARIO CINECA - SUPERCOMPUTING APPLICATIONS AND INNOVATION (ITALIA)
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD - RESEARCH SERVICES (UNITED KINGDOM)
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (UNITED STATES)
  • UNIVERSITA DEGLI STUDI DI TORINO - NEUROSCIENCE/MEDICAL SCHOOL/PHYSIOLOGY (ITALIA)
  • UNIVERSITY OF BEDFORDSHIRE - DEPARTMENT OF COMPUTER SCIENCE & TECHNOLOGY (UNITED KINGDOM)
  • UNIVERSITAET BERN - INSTITUTE FOR SURGICAL TECHNOLOGY AND BIOMECHANICS (SCHWEIZ/SUISSE/SVIZZERA)
Quadro di finanziamento
  • 7FP-ICT : TECNOLOGIE DELL’INFORMAZIONE E DELLA COMUNICAZIONE: priorità tematica 3 nell'ambito del programma specifico “Cooperazione” recante attuazione del Settimo programma quadro (2007-2013) di attività comunitarie di ricerca, sviluppo tecnologico e dimostrazione
Area di interesse
  • Unione Europea